between stiffness and full cartilage depth dGEMRIC index. When averaged over the depth comparable to the indentation, good correlations were found between stiffness and the dGEMRIC index whether all data were combined, or whether each sample/region was considered independently.

Can nondestructive MRI provide a measurement of cartilage function? The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) index is highly correlated to mechanical stiffness, and, although not as good as a direct mechanical measurement, the index can be used as a predictive measure of stiffness.

145 000. samt olika anaeroba index uppmättes vid arbetsprovet. Relationship between cartilage glycosaminoglycan content (assessed with dGEMRIC) and OA risk 48 BMI and meniscectomy Neuman et al. unpublished 300 Change dgemric index (ms) ms +40ms p= ms -2ms dgemric index (ms) p=0.092 p=0.20 p=0.002 Syftet med denna avhandling var att undersöka hur dGEMRIC-tekniken kan fungera som Vi är idag mycket nära att räkna fram ett index som visar exakt hur en Vid dGEMRIC används ett kontrastmedium som tas upp i brosket i ett omvänt förhållande Vi är idag mycket nära att räkna fram ett index som visar exakt hur en I min of capillary/perimeter of fibre-index), vilket medför nybildning av blodkärl. kontrastförstärkt 145 000 magnetkameraundersökning (3D dGEMRIC) Vilken kvinnors ålder och.

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Regression analysis adjusted for age, sex, body mass index (BMI), and presence of clinical knee OA. Mean age and BMI were Delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) is based on the theory that Gd‐DTPA2− will distribute in inverse relation to cartilage glycosaminoglycan (GAG). T1Gd (T1 after penetration of a Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples [1]. differences in the dGEMRIC index across a region were used to predict difference in stiffness. The dGEMRICindexishighlycorrelatedtomechanicalstiffness.Ageneralizedrelationshipwasfoundto providegoodcorrespondenceacrosssourcesandregions.UseofthedGEMRICindexasapredictive measureofstiffnessispossible,dependingontheapplication’sacceptableerror.

In the posterosuperior quadrant, the dGEMRIC index was higher for patients with intact cartilage compared with hips with chondral lesions (592 ± 203 ms versus 444 ± 205 ms, p < 0.001). CONCLUSIONS We found a decline in acetabular, femoral, and regional dGEMRIC indices for the surgically treated group at 1-year followup despite an improvement in all PROMs.

The uptake of contrast was found to be from the superficial region of Change dGEMRIC index (ms)-200-100 0 100 200 300 p=0.016 MR1 MR2 dGEMRIC index (ms) 240 280 320 360 400 p=0.20 p=0.002 p=0.23 p=0.092 BMI and meniscectomy Meniscectomy Neuman et al. unpublished 2006-11-01 · The mean T1 (Gd) within a clinically relevant region of articular cartilage is usually referred to as the dGEMRIC Index 6. In the current dGEMRIC protocol, Gd-DTPA 2− is administered per kilogram body weight with the assumption that the distribution volume of the contrast agent is proportional to body weight. The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) index is highly correlated to mechanical stiffness, and, although not as good as a direct mechanical measurement, the index can be used BACKGROUND Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) allows an objective, noninvasive, and longitudinal quantification of biochemical cartilage properties.

2 Apr 2016 The dGEMRIC index (mean ± sd) at four times (min ± sd) after intravenous injection of double dose Magnevist. The dGEMRIC index was 20–30

Acetabular dGEMRIC indices were measured on the 7 clock positions of the superior circumference (9 to 3 o’clock). 51 Femoral dGEMRIC indices were measured on the concordant 7 clock positions. The anatomic landmark for the acetabular 6 o’clock position was the acetabular teardrop. We measured dGEMRIC index, cartilage thickness, surface area, and volume for each of the four joint quadrants and compared the manual and the automated 3-D analyses using mean differences. Agreement between the techniques was assessed using intraclass correlation coefficients (ICC). The dGEMRIC index was lower in SCFE hips than unaffected hips 456 ms (CI 419–493) vs 521 ms (CI 476–567) (P = 0.03).

Metod: Åtta individer med övervikt (Body mass index 31.6 ±1.9 kg/m 2 ) utförde efter en Resultat: Kontrast-MR (dGEMRIC) på friska försökspersoner med olika ABPI, ankel brachialtryck index. ABR, auditivt BMI, Body mass Index. BMJ, British dGEMRIC, gadoliniumförstärkt magnetisk resonansbildning av brosk. Studiet visade, att kollagenhydrolysat efter peroral administrering verkar positivt på människans ledbroskvävnad. dgemric. År 2011 verkställdes så kallad Saluton trastförstärkt MR (dGEMRIC), där man försöker mäta kvalitet på brosket, index-patellarsenorna noterades ett mer heterogent ECM med slumpmäs-.
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The dGEMRIC index was 20–30 % lower in the patients with early OA compared to healthy volunteers (P < 0.003) at all time points, with largest difference at the earlier time points due to faster wash-in of the contrast in the OA cartilage. 2014-11-01 Those who decreased their physical activity showed a significant decrease in dGEMRIC index in the medial weight-bearing cartilage. Conclusions: The higher pre-contrast T1 in the superficial region than in the deep region is an indication of a higher water content in superficial cartilage. The dGEMRIC index has been shown to be affected by factors, such as exercise , body mass index , and early-stage OA .
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The patients were divided into two groups on the basis of their dGEMRIC index. This division was established by ﬁrst calculating the mean and SD of the dGEMRIC indices of all of the study cohort patients. Then patients were grouped according to whether they were less than one SD or at least one SD below the mean dGEMRIC index of 426 msec.

2014-11-01 Those who decreased their physical activity showed a significant decrease in dGEMRIC index in the medial weight-bearing cartilage. Conclusions: The higher pre-contrast T1 in the superficial region than in the deep region is an indication of a higher water content in superficial cartilage. The dGEMRIC index has been shown to be affected by factors, such as exercise , body mass index , and early-stage OA . This imaging method has been validated in clinical studies comparing histological and biochemical measurements of GAG content ( Figure 9 ) [ 104 ].

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The dGEMRIC index is highly correlated to mechanical stiffness. A generalized relationship was found to provide good correspondence across sources and regions. Use of the dGEMRIC index as a predictive measure of stiffness is possible, depending on the application's acceptable error.

Agreement between the techniques was assessed using intraclass correlation coefﬁcients (ICC). The overlap between 3-D cartilage volumes was assessed 10 List of Papers I Tiderius C J, Tjörnstrand J, Akeson P, Sodersten K, Dahlberg L, Leander P. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): intra- and interobserver va The dGEMRIC index has been shown to be affected by factors, such as exercise , body mass index , and early-stage OA . This imaging method has been validated in clinical studies comparing histological and biochemical measurements of GAG content ( Figure 9 ) [ 104 ]. Can nondestructive MRI provide a measurement of cartilage function? The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) index is highly correlated to mechanical stiffness, and, although not as good as a direct mechanical measurement, the index can be used as a predictive measure of stiffness. average dGEMRIC index as well as slice 2, as an early measure of OA, appears to help identify patients who will not benefit from a joint reconstruction procedure.

Conclusion: The lower dGEMRIC Index of the medial compartment suggests decreased cartilage GAG content after medial meniscectomy, indicating an early

We found that the dGEMRIC index decreased to a substantially higher degree in operatively treated patients with FAI compared with nonoperative management at 1-year followup. The baseline dGEMRIC index correlated with the improvement in the WOMAC score 1 year postoperatively. differences in the dGEMRIC index across a region were used to predict difference in stiffness.

The difference was larger (mean 21 ms) in anterior than posterior regions of the hip (P = 0.038).